Anthropic Claude Opus 4.5 vs Google Gemma 3n E4B Instructed
Detailed comparison for LLMs
On Guardion's LLM vulnerability Benchmark, Anthropic Claude Opus 4.5 is the more secure of the two: Claude Opus 4.5 scores 3.4% and Gemma 3n E4B Instructed scores 49.0% on attack success rate (ASR) (lower is better). One or both scores are estimated from public safety evaluations pending a Guardion benchmark run.
Head-to-Head Overview
Claude Opus 4.5 is the overall winner in this comparison!
Attack Success Rate (lower is safer)
ASR for Anthropic Claude Opus 4.5 vs Google Gemma 3n E4B Instructed. Green marks the safer model on each metric. Only the overall score is available for estimated models.
Overall (ASR)
TAP Attack Method (ASR)
Crescendo Attack Method (ASR)
Zero-Shot (ASR)
Key Highlights
- Anthropic Claude Opus 4.5 has a lower Overall (ASR).
Security Profile
Outward is better on every axis.
Frequently asked questions
Is Anthropic Claude Opus 4.5 or Google Gemma 3n E4B Instructed more secure?
On Guardion's LLM vulnerability Benchmark, Anthropic Claude Opus 4.5 is the more secure of the two: Claude Opus 4.5 scores 3.4% and Gemma 3n E4B Instructed scores 49.0% on attack success rate (ASR) (lower is better). One or both scores are estimated from public safety evaluations pending a Guardion benchmark run.
What is the attack success rate (ASR) of Claude Opus 4.5 vs Gemma 3n E4B Instructed?
Claude Opus 4.5 has a 3.4% ASR and Gemma 3n E4B Instructed has a 49.0% ASR — the share of adversarial prompts that succeed across zero-shot, TAP, and Crescendo attacks. Lower is safer.
How were Claude Opus 4.5 and Gemma 3n E4B Instructed tested?
Both were red-teamed with the HarmBench framework across zero-shot, TAP (Tree of Attacks with Pruning), and Crescendo multi-turn attacks, scored by Attack Success Rate.